Multivariate analysis GWAS analysis to determine genetic variants associated
with endophenotypes of Alzheimer's disease
 
   Lead Investigator:    Priya Bhatt
   Institution      :    University of Southern California
   E-Mail           :    priya.bhatt@ini.usc.edu
   Proposal ID      :    380



   Proposal Description:
   Abstract: We plan to test our central hypothesis and achieve the objective of this proposal by pursuing the following two specific aims:                                                                                                               1. Identify appropriate multiple outcomes within the NACC dataset as clinically important endophenotypes correlated with AD.                                      2. Implement and compare the results from two different multivariate analysis techniques in the NACC dataset to search for novel genetic variants via GWAS      analysis.                                                                                                                                                           The expected outcomes described by the two aims will fulfill the objective of     identifying new genetic variants associated with AD using analysis techniques     never tried with GWAS data in AD.  The results are expected to have a positive impact because the identification of new genetic variants can provide new targets for treatment in AD in addition to advancing the fields of bioinformatics and AD research.